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Other drugs may interact with sevelamerincluding prescription and over-the-counter medicinesvitaminsand herbal productsTell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Patients with chronic renal failure are predisposed to developing metabolic acidosisWorsening of acidosis has been reported upon switching from other phosphate binders to sevelamer in a number of studies where lower bicarbonate levels in the sevelamer-treated patients compared to patients treated with calcium-based binders were observedCloser monitoring of serum bicarbonate levels is therefore recommended.
In all of the studiesthe main measure of effectiveness was the change in blood phosphate levels between the start and the end of treatment.
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genzyme expects that the market potential for renagel will surpass 500 million within five years and that it will reach 1 billion within the decade.